Multiple pathways for NAD+ intake
|In this new study, researchers investigated intracellular NAD+ (iNAD) levels are regulated in several different types of healthy cells exposed to extracellular NAD+ (eNAD).They found eNAD+ more than doubled the quantity of iNAD+ in the cells through 3 preferred pathways.|
- direct import across the cell membrane of intact NAD+
- conversion of NAD+ to NMN, then imported by the NMN transporter Slc12a8
- further conversion of NMN to NR, then imported by NRK1
|In effect, when given a good supply of eNAD+, cells used all pathways to take in more NAD+. |
Once iNAD+ was sufficient, pathways for importation of more NAD+ were shut down.
The regulation of iNAD+ levels demonstrated in this research should be comforting to those worried about potential negative side effects from supplementation with NAD+ and its immediate precursors, as the cells studied here have an efficient means of limiting importation of excess NAD+ and precursors.
Since NAD+ is by far the most stable of these metabolites in the bloodstream and is able to utilize more pathways to increase intracellular NAD+, this study lends significant support to the use of NAD+ supplementation (vs NMN or NR) as a means of restoring NAD+ inside of cells.
Fisetin Reduced Senescence, Inflammation and Mortality Following Pathogen Exposure
|A new study, published in Science,discovered that senolytic therapies significantly reduced mortality, cellular senescence, inflammatory markers and increased antiviral antibodies in older mice infected with SARS-CoV-2.|
Fisetin is known to reverse age-related tissue damage and extend the median lifespan of mice, even when administered late in life, with no observable adverse effects.
64% of the Fisetin-treated male mice survived long-term with a significant extension of overall lifespan. In old mice treated with Fisetin, antibodies against the virus were increased to youthful levels by day 16.See our Liposomal Fisetin
Apigenin Alleviates Senescence via Modulation of SIRT1 – NAD+
|It is well known that Apigenin has anti-oxidant, anti-inflammatory and liver-protecting effects. The efficacy of Apigenin for lung aging, however, has not been reported. |
This new study shows Apigenin reduced senescence-associated activity, promoted cell growth, increased the activation of silent information regulator 1 (SIRT1) and nicotinamide adenine dinucleotide NAD+.
These findings suggest that Apigenin is a promising phytochemical for reducing the impact of senescent cells in age-related lung disease.