Multiple pathways for NAD+ intake
| In this new study, researchers investigated intracellular NAD+ (iNAD) levels are regulated in several different types of healthy cells exposed to extracellular NAD+ (eNAD).They found eNAD+ more than doubled the quantity of iNAD+ in the cells through 3 preferred pathways. |
- direct import across the cell membrane of intact NAD+
- conversion of NAD+ to NMN, then imported by the NMN transporter Slc12a8
- further conversion of NMN to NR, then imported by NRK1
| In effect, when given a good supply of eNAD+, cells used all pathways to take in more NAD+. Once iNAD+ was sufficient, pathways for importation of more NAD+ were shut down. The regulation of iNAD+ levels demonstrated in this research should be comforting to those worried about potential negative side effects from supplementation with NAD+ and its immediate precursors, as the cells studied here have an efficient means of limiting importation of excess NAD+ and precursors. Since NAD+ is by far the most stable of these metabolites in the bloodstream and is able to utilize more pathways to increase intracellular NAD+, this study lends significant support to the use of NAD+ supplementation (vs NMN or NR) as a means of restoring NAD+ inside of cells. |
Fisetin Reduced Senescence, Inflammation and Mortality Following Pathogen Exposure
| A new study, published in Science,discovered that senolytic therapies significantly reduced mortality, cellular senescence, inflammatory markers and increased antiviral antibodies in older mice infected with SARS-CoV-2. Fisetin is known to reverse age-related tissue damage and extend the median lifespan of mice, even when administered late in life, with no observable adverse effects. 64% of the Fisetin-treated male mice survived long-term with a significant extension of overall lifespan. In old mice treated with Fisetin, antibodies against the virus were increased to youthful levels by day 16.See our Liposomal Fisetin |
Apigenin Alleviates Senescence via Modulation of SIRT1 – NAD+
| It is well known that Apigenin has anti-oxidant, anti-inflammatory and liver-protecting effects. The efficacy of Apigenin for lung aging, however, has not been reported. This new study shows Apigenin reduced senescence-associated activity, promoted cell growth, increased the activation of silent information regulator 1 (SIRT1) and nicotinamide adenine dinucleotide NAD+. These findings suggest that Apigenin is a promising phytochemical for reducing the impact of senescent cells in age-related lung disease. |
